OL-023 Modeling dynamics of five acutely HBV infected chimpanzees

Hepatitis B antigens in serum and liver of chimpanzees acutely infected with hepatitis B virus.

We report the temporal patterns of various immunohistological and serological parameters of acute self-limited hepatitis B virus infection of two chimpanzees, and we provide evidence that the synthesis of hepatitis B core antigen precedes that of hepatitis B surface antigen. Our data suggest that existence of a biphasic hepatitis B virus infection involving a hematogenous reinfection of the liv...

Prevalence of isolated anti-HBc in previously HBV infected individuals

Background: The outcome of Hepatitis B virus (HBV) infection is chronic or resolved HBV infection. Over the time, the levels of HBsAg or Anti-HBs declined and were not detectable in their sera and was named as isolated anti-HBc. The purpose of this study was to assess the prevalence of isolated anti-HBc in previously HBV infected individuals.Methods: From April 2000 to September 2008, the resul...

Stability ‎a‎nalysis of the transmission dynamics of an HBV model

‎Hepatitis B virus (HBV) infection is a major public health problem in the world today‎. ‎A mathematical model is formulated to describe the spread of hepatitis B‎, ‎which can be controlled by vaccination as well as treatment‎. ‎We study the dynamical behavior of the system with fixed control for both vaccination and treatment‎. ‎The results shows that the dynamics of the model is completely de...

The Role of Proliferating Infected Hepatocytes on the Dynamics of an HBV-infected Liver

Chronic hepatitis B (HBV) infection is a major cause of human suffering, and a number of mathematical models have examined within-host dynamics of the disease. Previous models assume that infected hepatocytes do not proliferate; however, the effect of HBV infection on hepatocyte proliferation is controversial, with conflicting data showing both induction and inhibition of proliferation. With a ...

The Relationship between HBSAG and HBV DNA in HBV-Infected Blood Donors